Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors

Bioorg Med Chem Lett. 2010 Dec 1;20(23):6915-9. doi: 10.1016/j.bmcl.2010.10.004. Epub 2010 Oct 27.

Abstract

Recently the insuline-like growth factor receptor (IGF-1R) emerged as a promising target structure for the development of novel anti-cancer agents. IGF-1R plays a central role in both tumour progression and resistance development against anti-cancer drugs. We discovered 1-aza-9-oxafluorene derivatives as novel lead structures with submicromolar activities against IGF-1R. Structure-activity relationships (SARs) on a series of related receptor tyrosine kinases (RTKs) are discussed in the context of available crystal structures. A preliminary selectivity-profiling is demonstrated for the first compound series. Antiproliferative tumour cell line screening studies yielded one candidate as a promising cytostatic agent without significant toxic effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / pharmacology
  • Benzylamines / chemical synthesis
  • Benzylamines / pharmacology*
  • Cell Line, Tumor
  • Computer Simulation
  • Drug Discovery / methods*
  • Humans
  • Protein Binding
  • Receptor Protein-Tyrosine Kinases / chemistry
  • Receptor, IGF Type 1 / antagonists & inhibitors*
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Benzylamines
  • Receptor Protein-Tyrosine Kinases
  • Receptor, IGF Type 1